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Burning in the Mouth, Fire in the Belly:
Why Some Like It Hotter Than Others

by Dave DeWitt

Excerpted from The Pepper Encyclopedia (William Morrow & Co., 1999).

The sensation of heat created by capsaicin in chiles is caused by the irritation of the trigeminal cells, which are pain receptors located in the mouth, nose, and stomach. These sensory neurons release substance P, a neuropeptide chemical messenger that tells the brain about pain or skin inflammation. Repeated consumption of chile peppers depletes nerves of substance P, which is the reason people eventually build up a tolerance to capsaicin and can eat hotter and hotter foods.

When applied topically to treat skin pain, capsaicin "triggers a burst of the neuropeptide substance P from the C fibers," according to the Journal of the American Medical Association, and this is what causes the initial burning sensation. Repeated use of capsaicin also prevents the nerve endings from making more substance P, and thus further pain signals from the skin are greatly diminished or completely eliminated as long as the capsaicin is applied. When the capsaicin treatment is concluded, the substance P stores revert to normal.

There is a great deal of confusion about the effects of capsaicin on the tongue and taste buds, starting with the notion that men who can eat the hottest peppers are somehow more masculine or "macho." The real truth is that these men are not macho, they're nontasters. About 50 percent of the population are regular tasters, meaning that they have an average number of tastebuds per square centimeter on their tongue. The remaining population is evenly divided between supertasters, who have many more tastebuds, and the nontasters, who have less to practically none. The supertasters are almost twice as sensitive to sweet, bitter, and burnings tastes, while the nontasters enter jalapeño-eating contests.

Sometimes, of course, normal tasters and supertasters eat food which is simply too hot and the tongue and mouth can suffer blistering from contact dermatitis. This certainly harms the taste buds, but they are usually replaced in about two weeks, according to John Kinnamon, a University of Colorado neurobiologist.

But let's take a closer look at those tastebuds.

Those little bumps that are all over the mouth, including the roof, are really taste papilli, in which the tastebuds are housed. Capsaicin mostly affects the apex (tip), which is more sensitive to salty and sweet substances, and not the radix (base) of the tongue, which is more responsive to bitter tastes. Along with the tastebuds in the mouth are the trigeminal cells mentioned earlier, which are sensitive to touch, temperature, and pain.

Generally speaking, people who love chiles claim that they enhance the tastes of other foods, while people who avoid fiery foods contend that chiles reduce or mask food flavors. In fact, it has long been rumored that the capsaicin in chile peppers damages or destroys the tastebuds; noted chef Julia Child has made such a claim. There have been numerous studies on the subject of capsaicin desensitization, which generally have people judge the intensity of the taste of salt or citric acid after the mouth is treated with varying strengths of a capsaicin solution.

Desensitization does occur, causing a decrease in both the taste and tactile sensations on the tongue, but this effect seems to be temporary and does not destroy the tastebuds.

In fact, one study done by Tracey Karrer and Linda Bartoshuk of the Yale University School of Medicine, reported that in the sour and bitter taste tests: "As subjects recovered from capsaicin desensitization, their responses were enhanced in some cases to values higher than the precondition." This would seem to indicate that although capsaicin desensitizes the taste buds, tastes seem to be enhanced after recovery. They also noted: "Anecdotally, several subjects gave ratings that seemed to indicate that, after desensitization, they developed sensitivity to tactile components or taste components that they had previously not sensed." However, an earlier study of theirs indicated that people who eat chiles every day are in a constant state of desensitization, and consequently have less of an ability to perceive tastes. Also, desensitization means more of a tolerance for capsaicin, so the same level of heat would not seem so hot to them.

Interestingly enough, there may be a methodology factor at work as well. In an experiment by Beverly Cowart of the Monell Chemical Senses Center, where the capsaicin was actually mixed with what was being tasted, "no reduction in perceived taste intensity, relative to the control condition, was observed." Cowart noted that periodic rinses always cause desensitization where mixtures do not, leading her to conclude: "Much of the apparent masking of taste intensity in the presence of oral irritation is not directly related to the irritation level but is sensitive to procedural variation." So typically, we are left with conflicting scientific studies.

Dr. Barry Green of the Monell Chemical Senses Center theorizes that the conflict may have something to do with cognitive psychology. In his experiments, some people where able to taste many flavors after eating chiles, but others were not. As there are holistic people and analytical people in the practice of medicine, he sees the same dichotomy in the world of food. Some people see fiery foods and think, "This is ridiculously hot--I can't taste a thing," while others use their analytical abilities and think, "This is great--I can taste all these incredibly strong flavors." After all, no matter how scientific the experiment, taste is still subjective. Dr. Green noted: "The easiest explanation for why people like pain from their food is simply that it adds a whole new dimension to flavor."

Cooling the Bur

Many substances have been proposed as an antidote in the mouth to the heat of chiles, including water, milk, sugar, bread, citrus fruits, beer, and other carbonated beverages. The theory is that such substances can either wash away or dilute the capsaicin, or, like the bread, can absorb it. The problem is that the capsaicin is bound to the nerve receptor sites in the mouth and is not easily dislodged or diluted. Remember that capsaicin is very miscible with alcohol, fats, and oils, but not very miscible with water.

In a 1990 study at the University of California, Davis, Christina Wu Nasrawi and Rose Marie Pangborn reported that a ten percent sucrose solution at 20 degrees C. was just as effective as milk at 5 degrees C. A 5 percent ethanol solution was no more effective than water at cutting the burn. However, the effectiveness of sugar in warm water revives folk tales of it being an Asian cure for a chile overdose in the mouth. Richard Sterling, travel editor of Fiery Foods & Barbecue Magazine, wrote to us that a waiter in Pattaya Beach, Thailand, once dropped a cube of sugar into Richard's too hot Dom Yom, or spicy prawn soup. The heat level dropped noticeably and then Richard observed that the condiment trays in Thai restaurants often include a small jar of sugar.

During a search to verify the ultimate cure for heat in 1989, the late John Riley, editor-publisher of the quarterly journal Solanaceae, tested various remedies reputed to remove the heat of the capsaicin in chile peppers. In each test, a slice of serrano chile was chewed for one minute, and then one of the following remedies was applied. The amount of time until the burning sensation eased was measured and the results were recorded.

Remedy Total Minutes

  • Rinse the mouth with water only 11

  • Rinse the mouth with one Tablespoon olive oil 10

  • Drink one-half cup heavy fruit syrup 10

  • Rinse mouth with one tablespoon Glycerine 8

  • Drink one-half cup milk, rinsing well 7

Milk was the winner, and indeed, dairy products have long been reputed to be the best cool-downs for the burning effects of capsaicin in chiles. But why?

Scientists now believe that casein in the milk is responsible for its cooling effects. According to Robert Henkin of The Taste and Smell Clinic in Washington, D.C., casein is a phosphoprotein that acts as a detergent and strips the capsaicin from the nerve receptor binding sites in the mouth which are contained in the taste papilli. The casein in milk is in the form of calcium caseinate, which constitutes about three percent of milk. Other possible cool-downs containing casein include milk chocolate and some beans and nuts.

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Overdosing on Capsaicin

by Dave DeWitt

Given the fact that some manufacturers are using one million Scoville Unit oleoresins to manufacture super-hot sauces, the question comes up about the dangers of capsaicin. The biggest danger, of course is death. Is it possible? Can capsaicin kill you in high enough dosages?

In order to determine the lethal toxic level of capsaicinoids in animals, and to extrapolate that level for humans, researchers in 1980 performed a rather gruesome experiment with mice, rats, guinea pigs and rabbits. Pure crystalline capsaicin (16 million Scoville Units) was administered intravenously, subcutaneously, in the stomach, and applied topically until the animals died. The lethal toxic doses of capsaicin, measured in milligrams per kilogram of animal weight ranged from a mere .56 milligrams when administered intravenously, to 190 milligrams when consumed, to 512 milligrams when applied topically--which means that the poor animals were drowned in it. Indeed, the probable cause of death in all cases was presumed to be respiratory paralysis. Guinea pigs were the most sensitive to capsaicin, while rabbits were less susceptible. The author of the study, T. Glinsukon, concluded that the acute toxicity of capsaicinoids as a food additive in mankind was negligible. If humans are about as sensitive as mice, the acute fatal toxicity dose for a 150 pound person would be about thirteen grams of pure, crystalline capsaicinoids, which frankly, sounds high to us. We think that less than that would be lethal.

There have been investigations of dangerous doses for humans of the various substances that have capsaicin as an ingredient. For example, C.L. Winek conducted a study that was published in Drug and Chemical Toxicology that examined the overdose potential of Tabasco® Sauce. He concluded that a person of average weight would have to consume nearly a half gallon of the sauce to overdose and become unconscious.

In a related study, rats were fed large amounts of Tabasco® Sauce and suffered "no gross or microscopic pathological changes or any significant biochemical changes in the animals." Their growth rate also remained normal. In a similar study, rats were fed crude extracts of chile pods and crystalline capsaicinoids by stomach tube while allowed access to normal food and water. None of the rats died and they all appeared normal throughout the study. Of course, the rats were killed and then autopsied, but no gross pathological changes were detected.

Humans have also acted as guinea pigs with oleoresin capsicum, which is the concentrated heat ingredient in super-hot sauces with names using words like "insanity," "death," and "suicide." These sauces are tasted at food shows by people who have no idea of how hot they are. Some people, with few tastebuds in the mouths, are not bothered by the extreme heat. But most people react very negatively to the super-hot sauces, experiencing severe burning and sometimes blistering of the mouth and tongue. Other immediate responses have included shortness of breath, fainting, nausea, and spontaneous vomiting. People should be very careful of commercial hot sauces that list oleoresin capsicum as an ingredient, and taste them in small quantities.

Aside from the above possible adverse effects, the super-hot sauces will not seriously harm you. "Comprehensive nutritional studies have not shown any adverse effects of chile or capsaicinoids even at ten times the maximum use levels," wrote the one world’s experts on capsaicin, V.S. Govindarajan, author of the mammoth study, Capsicum--Production, Technology, Chemistry and Quality. But even if you do overindulge in super-hot sauces, do not worry, for they are quickly metabolized in the liver and excreted in the urine within a few hours. (Excerpted from The Chile Pepper Encyclopedia, by Dave DeWitt, William Morrow & Co., 1999).

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Interesting Articles


The Healing Powers of Hot Peppers
by Melissa T. Stock and Kellye Hunter

Part 1: Cayenne As a Curative

"And the fruit thereof shall be for meat, and the leaf thereof for medicine" (Ezekiel 47:12)

An entry from the journal of Priddy Meeks, a doctor in mid-nineteenth century Utah, sets the scene for our special report on the medicinal uses of chile peppers:

"He reached Parowan with both feet frozen above his ankles. He was left with me to have both feet amputated as it was thought there was no possible chance to save his life without amputation. I was at my wits end to know what to do. I saw no possible chance for amputation. An impulse seemed to strike my mind as tho by inspiration that I would give him cayenne pepper inwardly and see what effect that would have on the frozen feet.

"I commenced by giving him rather small doses at first, about three times a day. It increased the warmth and power of action in the blood to such a degree that it gave him such pain and misery in his legs that he could not bear it. He lay down on his back and elevated his feet up against the wall for three or four days and then he would sit in a chair...

"That was all the medical treatment he had and to my astonishment and to every one else that knew of the circumstances, the sixteenth day after I gave him the first dose of pepper he walked nine miles...and said he could have walked as far again."

The warm glow from eating chile is more than ecstasy--it's energy, it's enlivenment, it's...an expectorant. Chile enthusiasts know the playful side of their favorite condiment, but many do not know it has a working side as well.

Chile, therapeutically available as cayenne, has an impressive history as an herbal remedy and a general health aid, and we thought readers would be interested to know more about the health benefits of one of their favorite foods. What follows is an overview of scientific research and historical testimony, combined with the stories of people who have experienced the healing powers of hot peppers for themselves. It is important to remember that cayenne is not a miracle cure and should be used in addition to, rather than instead of, conventional medication. Always consult your physician before initiating or changing any medical treatment.

 

First, a Little Background

Cayenne is available in herb shops and health food stores as bulk powder, capsules, and tincture. It contains vitamins A and C, as well as calcium, phosphorus, iron, potassium, thiamine (B1), riboflavin (B2) and niacin (B3). Over the last quarter century, it has been the subject of scientific studies in the areas of pain, digestion, and circulation, and there have been some interesting results. Long thought to be an irritant, capsaicin (the chemical that makes chile hot) is actually a counter-irritant--an irritation to an irritation--that reduces pain and swelling, and so is useful as a topical analgesic. It also stimulates circulation, aids in digestion, and breaks up congestion. Chile is a diaphoretic (perspiration producer), which helps people who live in hot climates regulate their body temperatures, and it serves as an antiseptic when directly applied to an affected area. It also has some limited blood thinning capabilities which are helpful in the treatment of high blood pressure and heart disease.

"I'm not saying that every person who takes capsicum is going to prevent atherosclerosis, but it (the herb) is taken that way," said Robin Dipasquale, who is in the final months of her study and training at Bastyr University in Seattle, a post-graduate four-year degree program for naturopathic physicians. She said that every person has a different threshold for capsaicin, and everyone who takes it experiences individual results.

 

Things Heat Up In Manitowoc County

When you think of the food associated with Wisconsin, thoughts drift to beer and brats, lots of cheese and...cayenne pepper. That's right, cayenne pepper.

Paul and Barbara Stitt definitely believe in the healing powers of hot peppers. When they decided they wanted to give something back to their community, no one would have ever guessed it would come in the form of cayenne pepper capsules.

"Our bakery, Natural Ovens, has done very well, so we wanted to give something back," said Stitt. That "something," they decided, would be to help improve the health of Manitowoc County. After discovering and researching the properties of cayenne pepper, Stitt, a biochemist by training, decided to design a program that would give away free cayenne capsules to anyone in their county interested in improving their health.

Since January, 1995 more than a thousand families have signed up for the program, which includes recommended diet changes, a medical history, and follow-up meetings at the bakery with program facilitator Paula Wagner.

Wagner, a long-time bakery employee says she loves working with the people on the program, and has seen incredible results from the participants.

"Each day brings news of people who are feeling a lot better because of the cayenne," she said. "They tell me of improved ulcers, heart disease, circulation, arthritis, and the list goes on." Each person in the program takes from one to four cayenne capsules a day, depending on their health problems. Since cayenne is an herb, not a drug, the bakery can dispense the capsules without any legal problems. Plus, according to Stitt, the cayenne is free (for up to six weeks), and each person is articipating voluntarily--anyone may quit at any time. "We've given away more than 150,000 capsules for free, and people keep coming back for more," he said. Stitt says that they'd like to give away more, and has been interviewed on local radio shows in his area and in the paper about his offer for free cayenne.

 

Digestive De-tox and Ulcer Afterburners

It was once believed that chile would burn out the lining of the stomach, but this has been disproved by doctors who have used cayenne, ironically, to relieve digestive distress, and more recently, by a medical study conducted in 1988 at the Baylor College of Medicine in Houston, which found that chile increases gastric secretions in the stomach but does no harm. Rob McCaleb, an ethnobotanist and president of the Herb Research Foundation in Boulder, Colorado, observes that various kinds of chile actually helps digestion and reduces flatulence by increasing the circulation in the stomach and intestines so that food is processed and absorbed more efficiently. Indeed, one of the reasons cayenne is often included in herbal blends is so that all the ingredients will be assimilated more productively.

Lee Klatt, 59, of Twin Rivers, Wisconsin, suffered with duodenal ulcers for twenty years, but after less than two weeks of taking cayenne, his symptoms were noticeably relieved.

"It always felt like I had a bobber in the base of my throat; it was like trying to swallow a cork," he said of the pent-up gas that was always in his stomach. "But now I can eat the rust off of nails again."

Klatt said he has tried other remedies, such as using dairy products in an attempt to coat his stomach, but none ever worked. It was Paul Stitts' offer on the radio that convinced Klatt to try cayenne. He began in mid-December by taking four 500-milligram capsules three times a day, and has now cut back to two capsules three times a day. Klatt said he receives no pay for his participation in the program, only the free cayenne, and his only cost is for extra cayenne which he buys from Stitts at a price of $15 for three hundred capsules.

In addition to the cayenne, Klatt said he tries to make healthy food choices by eating less red meat, drinking distilled water, avoiding dairy products, and eating a lot of fresh vegetables. Even so, he does not consider himself to be a strict dieter. "I don't go overboard and worry about cheating when I eat," he said. "If you're going to cheat make sure you can enjoy it because guilt will hurt your stomach and hurt you."

Since his treatment has been so successful, Klatt said he might reduce his cayenne intake, and then gradually stop treatment altogether; however, if this should this prove detrimental, he is not afraid of taking cayenne indefinitely to maintain good health. Not only has his stomach condition improved, he said, but his circulation is more efficient, making his feet and hands warmer than before. "I'm feeling in the pink, emphatically," he said.

Some people have even reported that their ulcers were healed through the use of cayenne. Although there is no scientific evidence to verify this, a 1991 study conducted at Kyoto Pharmaceutical University in Japan reported that capsaicin given orally decreased muscle contractions in the stomach and increased the flow of protective mucus. It seems that the body initially perceives chile as an invader, and in defense, secretes mucus in the digestive and respiratory tracts to flush it out. As a result, the stomach is coated and soothed and the nose begins to run, which is why chile is also effective in breaking up the congestion of a cold.

Dipasquale said the dosage of cayenne must be monitored carefully when treating ulcers. A proper dose, she said, will produce the protective mucosal coating, but if a patient ingests too much, the capsaicin will work its way through the mucosal surface and irritate the mucosal membranes in the digestive tract. "There's a very fine line between proper dosing and overdosing," she said.

A moderate overdose of cayenne is not harmful or damaging in the same way that excessive chemical drugs are, but untherapeutically high amounts can cause unnecessary pain and diminish healing properties. Many people have probably experienced the consequences of a mild overdose when a laxative effect kicks in the day after eating too much chile. This is the result of digestive tract irritation. Dipasquale also said that cayenne should only be taken when an ulcer is in a healing or calm phase, but never when it is acute or inflamed.

Additional digestive benefits of chile include the prevention of arterial blockage and the increase of fat metabolism. McCaleb said that chile can the lower blood level of low-density lipoprotein cholesterol (LDL), which contributes to atherosclerosis, without affecting high-density lipoprotein cholesterol (HDL), which retards atherosclerosis. A 1982 study done at Siriraj Hospital, Mahidol University in Bangkok found that chile triggers a short-term blood thinning, or clot- resisting response, but this is not one its main therapeutic uses. McCaleb said that a cayenne-garlic combination is much more effective for preventing stroke.

Furthermore, a 1986 study at the American Institute of Nutrition showed that capsaicin reduces the amount of triglycerides (stored fat) in the blood cells, as well as reducing fat deposits in the liver. And, a good piece of news for the weight-conscious: studies at the Oxford Polytechnic Institute found that eating hot chiles can raise the metabolism enough to burn 45 calories of a 700-calorie meal!

 

Author Anecdotes

 

The Mysterious Case of the Vari-Ghost Vein

It materialized one day when I was only eight years old, and has haunted me ever since. A varicose vein is like having a permanent bruise; it always hurts when pressed on or bumped, and sometimes it swells up and feels like it's going to burst.

The testimonies I read when researching this article were fascinating, but I must admit that I was a little skeptical--it was hard to believe that something so simple as cayenne could bring about such sudden changes to persistent problems. I really wanted to believe in the things I was writing, so I decided to try the stuff myself.

After only two days of taking cayenne capsules, I noticed, quite by accident, that my leg no longer felt bruised. I gingerly pressed my fingers on the familiar weak place, and to my astonishment, there was no pain. When I looked for the familiar swollen blue worm, I found instead, a thin blue line.

No, it's not completely healed, but neither is it the ugly vulnerable spot that it used to be. I'm reconsidering my forsaken career as a leg model, and even if that doesn't work out, hey, I'm only 33, I'm too young to have varicose veins. But best of all, it's a great relief not to be afraid anymore of legs that go bump in the night. --Kellye Hunter


The Toastie Tootsie Tale

When I first thought of writing an article story on the healing powers of peppers, it did not occur to me that I might benefit from them also. But the more I read about what cayenne could do, the more curious I became. And, well, I did have a slight problem that could use some improvement. Actually, a lot of improvement. The truth of the matter is that I have extraordinarily poor circulation. Not a big deal, unless those frigid footsies happen to touch you in the night. My loving husband still agreed to marry me despite the fact that I would probably wear wool socks to bed, winter and summer alike, for the next 106 years or so.

And then there was cayenne pepper. For the last month I have been taking the capsules and am happy to report that I have been virtually sockless since. My hands and feet really have warmed up. And I seem to have more energy, too. And since we don't have any children yet, I'm a little worried to take any more cayenne--you never know what might happen! --Melissa T. Stock

In Part 2 of "The Healing Powers of Peppers," Melissa T. Stock and Kellye Hunter investigate the use of capsaicin in combating pain, treating colds, and alleviating the conditions of certain cancer patients. Also, a bibliography of resources for the two-part series is included.

Melissa T. Stock and Kellye Hunter are former editors of Chile Pepper Magazine, and are now working for Fiery Foods, the official magazine of the National Fiery Foods Show, and Sunbelt Shows. This article was nominated for a 1996 James Beard journalism award for magazine writing on health and nutrition. Together with Dave DeWitt, they are currently working on a book titled The Healing Powers of Peppers, which will be published by Clarkson/Potter.

The following are cayenne pepper recipes for an assortment of ailments. Please consult a physician before you discontinue any medicines you are currently using, or have any serious health concerns or conditions.

 

A Spicy Remedy for Bruises

From Michael Castleman's The Healing Herbs, this is an alternative to menthol or other warming oils designed to help bruising.

1 cup vegetable oil, warmed

1/2 teaspoon cayenne powder

Mix the cayenne into the oil. One day after the initial injury, (the first day apply ice), gently rub the oil onto the affected area several times a day until the bruise clears. However, make sure you do not apply this to an area with broken skin.

 

Capsicum Cold Remedy and Tonic

Dr. J. Michael Queen swears by this remedy's astringent, mucous-reducing and general stimulating qualities. Use this regularly as a tonic for general health, or specifically to treat cold symptoms. Increase the amount of cayenne as your tolerance increases--use enough to feel the heat, but not be in pain.

1 inch-long piece of ginger root

1 1/4 cups very hot (not boiling) water

1 round tablespoon lavender flower

Frozen lemonade concentrate, to taste

1/4 teaspoon cayenne

Mash the ginger root in a garlic press, then place the juice and pulp into a small glass bowl. Add the hot water and lavender, and steep for 3 to 5 minutes. Strain the liquid into a cup, then add the lemonade concentrate and cayenne. Drink the entire mixture.

 

Hot Cayenne Tea

Andy Householder, the Owner of Hi-Co Western Products prescribes the following hot tea for a cold that won't go away.

1 quart of water

1 teaspoon cayenne powder

2 regular bouillon cubes

Place the water into a medium-sized sauce pan. Heat the water until boiling, then stir in the cayenne and bouillon cubes. Mix until thoroughly dissolved then cool until the broth is not too hot to drink. Drink as much as you can and repeat until all of the broth, or your cold symptoms are gone.

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